Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease
【Abstract】
This cross-sectional study evaluates the association between corticolimbic vulnerability to tau pathology as a continuous trait with clinicalpathologic heterogeneity and glial activation patterns in neuropathologically diagnosed Alzheimer disease.
【Author】
Naomi Kouri, Isabelle Frankenhauser, Zhongwei Peng, Sydney A. Labuzan, Baayla D. C. Boon, Christina M. Moloney, Cyril Pottier, Daniel P. Wickland, Kelsey Caetano-Anolles, Nick Corriveau-Lecavalier, Jessica F. Tranovich, Ashley C. Wood, Kelly M. Hinkle, Sarah J. Lincoln, A. J. Spychalla, Matthew L. Senjem, Scott A. Przybelski, Erica Engelberg-Cook, Christopher G. Schwarz, Rain S. Kwan, Elizabeth R. Lesser, Julia E. Crook, Rickey E. Carter, Owen A. Ross, Christian Lachner, Nilüfer Ertekin-Taner, Tanis J. Ferman, Julie A. Fields, Mary M. Machulda, Vijay K. Ramanan, Aivi T. Nguyen, R. Ross Reichard, David T. Jones, Jonathan Graff-Radford, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Kejal Kantarci, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Dennis W. Dickson, Val J. Lowe, Prashanthi Vemuri, Melissa E. Murray
【Keywords】
alzheimer's disease, heterogeneity, hippocampus, pathology, clinical, tau proteins, neuroimaging, macrophages, microglia, positron-emission tomography, magnetic resonance imaging, cd68 antigen, human 
【Journal】
JAMA Neurology(IF：12.3) Time：2024-04-16
